Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic Target.
Wei SunYongxiang ZouZheng CaiJinxiang HuangXinjie HongQiang LiangWei-Lin JinPublished in: Cancers (2022)
Overexpression of NNMT causes abnormal DNA methylation through regulation of the NAD/NADH ratio, which in turn leads to the downregulation of GAP43 and SIRT1, eventually altering the biological behavior of tumor cells.