Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome.
Naila MakhaniChristine LebrunAksel SivaSona NarulaEvangeline WassmerDavid BrassatJ Nicholas BrentonPhilippe CabreClarisse Carra DallièreJérôme de SezeFrancoise Durand DubiefMatilde IngleseMegan LangilleGuillaume MatheyRinze F NeuteboomJean PelletierDaniela PohlDaniel S ReichJuan Ignacio RojasVeronika ShabanovaEugene D ShapiroRobert T StoneSilvia TenembaumMar TintoreUgur UygunogluWendy VargasSunita VenkateswarenPatrick VermerschOrhun KantarciDarin T OkudaDaniel Pelletiernull nullPublished in: Multiple sclerosis journal - experimental, translational and clinical (2019)
Oligoclonal bands increased the specificity of magnetic resonance imaging criteria in children with Ped-RIS. Clinicians should consider testing cerebrospinal fluid to improve diagnostic certainty. There is rationale to include cerebrospinal fluid analysis for biomarkers including oligoclonal bands in planned prospective studies to develop optimal diagnostic criteria for radiologically isolated syndrome in children.