Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice.
Franziska RotherReinhard DeppingElena PopovaStefanie HuegelAriane HeilerEnno HartmannMichael BaderPublished in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2024)
The nuclear transport of proteins plays an important role in mediating the transition from egg to embryo and distinct karyopherins have been implicated in this process. Here, we studied the impact of KPNA2 deficiency on preimplantation embryo development in mice. Loss of KPNA2 results in complete arrest at the 2cell stage and embryos exhibit the inability to activate their embryonic genome as well as a severely disturbed nuclear translocation of Nucleoplasmin 2. Our findings define KPNA2 as a new maternal effect gene.
Keyphrases
- pregnancy outcomes
- genome wide
- high fat diet induced
- copy number
- birth weight
- stem cells
- pregnant women
- cell therapy
- cell cycle
- genome wide identification
- cell proliferation
- bone marrow
- skeletal muscle
- physical activity
- insulin resistance
- transcription factor
- weight loss
- replacement therapy
- childhood cancer
- genome wide analysis
- solid state