Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis.
Daria GusevaUrda RüdrichNika KotnikManuela GehringNikolaos PatsinakidisKonstantin AgelopoulosSonja StänderBernhard HomeyAlexander KappBernhard F GibbsEvgeni PonimaskinUlrike RaapPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
Our results indicate that BDNF-positive eosinophils are also localized in close proximity with nerve fibres in AD, suggesting a functional relationship between BDNF-expressing eosinophils and neuronal projections. These observations suggest that eosinophils may have considerable impact on pruritus by supporting sensory nerve branching.