Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus.

Hannah SwahnKun LiTomas DuffyMerissa OlmerDarryl D D'LimaTony S MondalaPadmaja NatarajanSteven R HeadMartin K Lotz

Published in: Annals of the rheumatic diseases (2022)

These single-cell studies identified a senescent pathogenic cell cluster that is present in cartilage and meniscus and has FAP and ZEB1 as main regulators which are novel and promising therapeutic targets for OA-associated pathways in both tissues.

Keyphrases

single cell
transcription factor
rna seq
epithelial mesenchymal transition
long non coding rna
rheumatoid arthritis
gene expression
extracellular matrix
stem cells
bone marrow
anterior cruciate ligament