Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter.
Prisca S LeferinkStephanie DoovesAnne E J HillenKyoko WatanabeGerbren JacobsLisa GasparottoPaulien Cornelissen-SteijgerMarjo S van der KnaapVivi M HeinePublished in: Annals of neurology (2019)
Astrocyte subtype cultures revealed disease-specific pathways in VWM. Cross-validation of human- and mouse-derived protocols identified human-specific disease aspects. This study provides new insights into VWM disease mechanisms, which helps the development of in vivo regenerative applications, and we further present strategies to study astrocyte subtype vulnerability in neurological disease. ANN NEUROL 2019;86:780-792.