Facile preparation of poly( N -isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapy.
Phornsawat BaipaywadNaeun RyuSoo-Seok ImUkjae LeeHyung Bin SonWon Jong KimHansoo ParkPublished in: Designed monomers and polymers (2022)
Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, and electrochemical sensors. Graphene oxide (GO) has unique physicochemical properties and can be used to restore conductivity through oxidation. In this study, we developed poly( N -isopropylacrylamide) (PNIPAM)-based nanogel systems containing GO for controlled in vitro drug delivery. The photothermal effects of the PNIPAM/GO- and PNIPAMAAM/GO-based nanogel systems were enhanced. The release of DOX from the PNIPAM/GO-based nanogel was achieved using the photothermal effect of near-infrared irradiation. Using a Cell Counting Kit-8 assay, the cytotoxicity of all conditions demonstrated that the PNIPAM composite-based nanogels were biocompatible with no significance.
Keyphrases
- cancer therapy
- carbon nanotubes
- drug delivery
- drug release
- ionic liquid
- molecularly imprinted
- photodynamic therapy
- single cell
- high resolution
- gold nanoparticles
- high throughput
- visible light
- cell therapy
- hydrogen peroxide
- stem cells
- emergency department
- mesenchymal stem cells
- squamous cell carcinoma
- atomic force microscopy
- bone marrow
- adverse drug
- locally advanced
- rectal cancer
- single molecule
- electron transfer
- nucleic acid
- high speed