Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
Yizhe ChenEric Aria FernandezCatherine RogerIsabel C Lopez-MejiaLluis FajasHonglei JiPublished in: FEBS letters (2022)
Adipose tissue regulates whole-body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin-dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue-specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat-specific genes, which are aggravated on high-fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet
- cell cycle
- high fat diet induced
- polycystic ovary syndrome
- multiple sclerosis
- metabolic syndrome
- type diabetes
- oxidative stress
- transcription factor
- skeletal muscle
- body mass index
- cell proliferation
- physical activity
- signaling pathway
- weight loss
- genome wide
- cell death
- pi k akt