Dominant vector changes during early wavebreak/spiral wave (Wiggers stage 1) in ventricular fibrillation: insights from the analysis of 100 electrophysiology studies.
Mariam MeddebKashif ChaudhrySaroj TimilsinaJagat MahatRamarao VunnamAashish AcharyaAlejandro Jimenez RestrepoVincent SeeStephen ShorofskyTimm DickfeldPublished in: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing (2021)
The predominant QRS vectors during early Wiggers stage 1 VF are not random and suggest an initial wavebreak more commonly in the right ventricle, followed by a transitional shift to the septum/left ventricle. Ethnicity, male gender, age, and co-morbidities result in directional preservation of initiating VF vectors possibly due to myocardial mass/fibrosis. Findings may allow new treatment/ablation approaches.
Keyphrases
- left ventricular
- pulmonary artery
- mitral valve
- pulmonary hypertension
- heart failure
- catheter ablation
- gene therapy
- mental health
- cardiac resynchronization therapy
- congenital heart disease
- pulmonary arterial hypertension
- radiofrequency ablation
- case control
- atrial fibrillation
- combination therapy
- liver fibrosis
- replacement therapy