Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid-β (Aβ) oligomers.
Luan Pereira DinizJuliana MorgadoAna Paula Bergamo AraujoLeticia Maria da Silva AntônioHannah Paola Mota-AraujoPedro de Sena Murteira PinheiroFernanda Savacini SagrilloGabriele Vargas CesarSérgio T FerreiraCláudia Pinto FigueiredoCarlos Alberto Manssour FragaFlávia Carvalho Alcantara GomesPublished in: British journal of pharmacology (2024)
These results contribute to unveiling the mechanisms underlying astrocyte role in AD and provide the rationale for using astrocytes as targets to new drugs for AD.