Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent HDL (High-Density Lipoprotein) Suppression of Necroptosis in Macrophages.
George E G KluckAlexander S QianEmmanuel H SakaryaHenry QuachYak D DengBernardo L TrigattiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Our findings demonstrate that HDL in vitro and ApoA1, in vivo, protect against necroptosis in macrophages and necrotic core formation in atherosclerosis, suggesting a pathway that could be a target for the treatment of atherosclerosis.