Predictive value of CD8/FOXP3 ratio combined with PD-L1 expression for radiosensitivity in patients with squamous cell carcinoma of the larynx receiving definitive radiation therapy.

Takeharu OnoKoichi AzumaAkihiko KawaharaTatsuyuki KakumaFumihiko SatoJun AkibaNorimitsu TanakaToshi AbeShun-Ichi ChitoseHirohito Umeno

Published in: Head & neck (2020)

We showed that high CD8/FOXP3 ratio combined with negative PD-L1 expression might be a useful biomarker of radiosensitivity in patients with SCC-L receiving definitive RT. We propose that coassessment of CD8/FOXP3 ratio and PD-L1 expression level in tumor cells can help predict potential radiosensitivity in patients with SCC-L.

Keyphrases

regulatory t cells
squamous cell carcinoma
radiation therapy
locally advanced
nk cells
risk assessment
rectal cancer
lymph node metastasis