Standardized Uptake Value for 18F-Fluorodeoxyglucose Is a Marker of Inflammatory State and Immune Infiltrate in Cervical Cancer.
John M FlobergJin ZhangNaoshad MuhammadTodd A DeWeesMatthew J InkmanKevin ChenAlexander J LinRamachandran RashmiKay JayachandranBrian T EdelsonBarry A SiegelFarrokh DehdashtiPerry W GrigsbyStephanie MarkovinaJulie K SchwarzPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
SUVmax is a prognostic marker in cervical cancer that is associated with activation of inflammatory pathways and tumor infiltration of myeloid-derived immune cells, particularly macrophages. Macrophages contribute to changes in cervical cancer glucose metabolism.See related commentary by Williamson et al., p. 4136.