The κ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats.
Johanna K Uhari-VäänänenAtso RaasmajaPia BäckströmVille OinioF Ivy CarrollMikko AiravaaraKalervo KiianmaaPetteri PiepponenPublished in: Psychopharmacology (2018)
The results provide further evidence that κ-opioid receptors play a role in controlling ethanol intake and that accumbal κ-opioid receptors participate in the modulation of the reinforcing effects of ethanol. Furthermore, the results suggest that κ-opioid receptor antagonists may be a valuable adjunct in the pharmacotherapy of ethanol use disorders.