Score performance of SAPS 2 and SAPS 3 in combination with biomarkers IL-6, PCT or CRP.
Michael JahnJan RekowskiRolf Alexander JánosiAndreas KribbenAli CanbayAntonios KatsounasPublished in: PloS one (2020)
Our analysis provided evidence that the risk stratification performance of the SAPS 3 and, to a lesser degree, also of the SAPS 2 can increase when combined with IL-6. A more accurate detection of aberrant or dysregulated systemic immunological responses (by IL-6) may explain the higher performance achieved by SAPS 3 + IL-6 vs. SAPS 3. Thus, implementation of IL-6 in critical care scores can improve prediction outcomes, especially in patients experiencing acute inflammatory conditions; however, statistical results may vary across hospital types and/or patient populations with different case mix.
Keyphrases
- end stage renal disease
- chronic kidney disease
- ejection fraction
- type diabetes
- newly diagnosed
- emergency department
- prognostic factors
- case report
- quality improvement
- weight loss
- drug induced
- hepatitis b virus
- adverse drug
- acute respiratory distress syndrome
- loop mediated isothermal amplification
- sensitive detection