Ligand-Enabled Palladium-Catalyzed Through-Space C-H Bond Activation via a Carbopalladation/1,4-Pd Migration/C-H Functionalization Sequence.
Su ChenPrabhat RanjanNagarajan RamkumarLuc Van MeerveltErik V Van der EyckenUpendra K SharmaPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp2 )-C(sp2 ) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provides a direct approach to introduce an oxadiazole core at a remote location without any functional group obligation, with moderate to good yields.
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