Treatment and outcome in children with tuberculous meningitis - a multi-centre Paediatric Tuberculosis Network European Trials Group study.

Stephanie TheeRobindra Basu RoyDaniel Blázquez-GameroLola Falcón-NeyraOlaf NethAntoni Noguera-JulianCristina LilloLuisa GalliElisabetta VenturiniDaniele Antonio PizzutoFlorian GötzingerNuria Martinez-AlierSvetlana VelizarovaFolke BrinkmannSteven B WelchMaria TsoliaBegoña Santiago-GarciaRalph SchillingMarc TebrueggeRenate Krügernull null

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

There was considerable heterogeneity in the use of TB drugs in this cohort. Despite few children presenting with advanced disease and the study being conducted in a high-resource setting, morbidity and mortality were high. Several risk factors for poor outcome were identified, which may aid prognostic predictions in children with TBM in the future.

Keyphrases

young adults
mycobacterium tuberculosis
emergency department
intensive care unit
hepatitis c virus
hiv infected
adverse drug
antiretroviral therapy
electronic health record