Anti-Inflammatory and Immunomodulatory Effect of High-Dose Immunoglobulins in Children: From Approved Indications to Off-Label Use.
Francesca ContiMattia MorattiLucia LeonardiArianna CatelliElisa BortolamediEmanuele FiliceAnna FettaMarianna FabiElena FacchiniMaria Elena CantariniAngela MiniaciDuccio Maria CordelliMarcello LanariAndrea PessionDaniele ZamaPublished in: Cells (2023)
In the light of the current imbalance between gammaglobulins' demand and availability, this review advocates the urgency of a more conscious utilization of this medical product, giving indications about benefits, risks, cost-effectiveness, and administration routes of high-dose immunoglobulins in children with hematologic, neurologic, and inflammatory immune dysregulation disorders, prompting further research towards a responsible employment of gammaglobulins and improving the therapeutical decisional process.