Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing.

Cristina ArceDiana VicenteVanessa SeguraNicla FlaccoFermi MontóLuis AlmenarJaime AgüeroJoaquín RuedaFrancesc Jiménez-AltayóElisabet VilaMaria Antonia NogueraPilar D'OconMaria Dolores Ivorra

Published in: British journal of pharmacology (2017)

The α1A -adrenoceptor subtype, through endothelial nNOS-derived NO, may act as a physiological 'brake' against the detrimental effects of excessive α1 -adrenoceptor-mediated vasoconstriction. Reduced α1A -adrenoceptor- and nNOS-mediated desensitization in aged patients could be involved in the age-dependent elevation of adrenergic activity.

Keyphrases

nitric oxide synthase
end stage renal disease
ejection fraction
newly diagnosed
oxidative stress
nitric oxide
endothelial cells
aortic valve
weight gain
pulmonary artery
body mass index
pulmonary arterial hypertension
physical activity
pulmonary hypertension
patient reported