Bacterial endotoxin decreased histone H3 acetylation of bovine mammary epithelial cells and the adverse effect was suppressed by sodium butyrate.

Jingbo ChenYongjiang WuYawang SunXianwen DongZili WangZhu ZhangYanli XiaoGuozhong Dong

Published in: BMC veterinary research (2019)

The results suggest one of the adverse effects of LPS on the lactation of bovine mammary gland epithelial cells was due to decreasing histone H3 acetylation through increasing HDAC activity, whereas the endotoxin-induced adverse effects were effectively suppressed by SB.

Keyphrases

histone deacetylase
high glucose
diabetic rats
inflammatory response
human milk
dairy cows
anti inflammatory
emergency department
endothelial cells
preterm birth