Rethinking the Application of Pemetrexed for Patients with Renal Impairment: A Pharmacokinetic Analysis.
Nikki de RouwRene J BoosmanAlwin D R HuitemaLuuk B HilbrandsElin M SvenssonHieronymus J DerijksMichel M van den HeuvelDavid M BurgerRob Ter HeinePublished in: Clinical pharmacokinetics (2021)
Renal function is more important for the clearance of pemetrexed than previously thought and this should be taken into account in patients with renal impairment. Furthermore, a third compartment may contribute to prolonged exposure to pemetrexed during drug washout.