Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt Licenses the Differentiation and Function of a Unique Subset of Follicular Helper T Cells in Response to Immunogenic Self-DNA in Systemic Lupus Erythematosus.
Zhenke WenLin XuWei XuSidong XiongPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Immunogenic self-DNA instructs ICOS-dispensable IL-17-positive Tfh cells via RORγt to produce an IgG anti-dsDNA response. As such, IL-17-positive Tfh cells are a promising therapeutic target for lupus patients.
Keyphrases
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- circulating tumor
- ejection fraction
- single molecule
- newly diagnosed
- systemic lupus erythematosus
- chronic kidney disease
- cell free
- peritoneal dialysis
- cell death
- prognostic factors
- regulatory t cells
- patient reported outcomes
- pi k akt
- disease activity
- nucleic acid
- cell proliferation
- circulating tumor cells