SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.

Caroline JunqueiraÂngela CrespoShahin RanjbarJacob IngberBlair ParrySagi RavidLuna B de LacerdaMercedes LewandrowskiSarah ClarkFelicia HoSetu M VoraValerie LegerCaroline BeakesJustin MargolinNicole RussellLee GehrkeUpasana Das AdhikariLauren A HendersonErin JanssenDouglas KwonChris SanderJonathan AbrahamMichael FilbinMarcia B GoldbergHao WuGautam MehtaSteven BellAnne E GoldfeldJudy Lieberman

Published in: medRxiv : the preprint server for health sciences (2021)

Antibody-mediated SARS-CoV-2 infection of monocytes activates inflammation and cytokine release.

Keyphrases

sars cov
respiratory syndrome coronavirus
nlrp inflammasome
dendritic cells
peripheral blood
oxidative stress
coronavirus disease