The use of methadone to facilitate opioid weaning in pediatric critical care patients: a systematic review of the literature and meta-analysis.
Leslie A DervanBeryl YaghmaiRobert Scott WatsonFredric M WolfPublished in: Paediatric anaesthesia (2017)
We did not identify sufficient evidence to recommend any particular methadone weaning strategy, or to recommend methadone over other medications or prescribed infusion weaning, for successful weaning of continuous opioid infusions in the pediatric intensive care setting.