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Drug survival of anakinra and canakinumab in monogenic autoinflammatory diseases: observational study from the International AIDA Registry.

Jurgen SotaDonato RiganteRolando CimazMarco CattaliniMicol FrassiRaffaele MannaLudovico Luca SicignanoElena VerrecchiaEmma AragonaMaria Cristina MaggioGiuseppe LopalcoGiacomo EmmiPaola ParronchiAlberto CauliEwa Więsik-SzewczykJosé Hernández-RodríguezCarla GaggianoMaria TarsiaMariam MourabiGaafar RagabAntonio VitaleClaudia FabianiBruno FredianiVittoria LamacchiaAlessandra RenieriLuca Cantarininull null
Published in: Rheumatology (Oxford, England) (2021)
IL-1 inhibitors display an excellent long-term effectiveness in terms of DRR, and their survival is not influenced by the biologic line of treatment. They display a favourable safety profile, which deserves, however, a close monitoring given its impact on treatment continuation. Special attention should be paid to molecular diagnosis and mutation penetrance, as patients carrying low-penetrance variants are more likely to interrupt treatment.
Keyphrases
  • end stage renal disease
  • chronic kidney disease
  • ejection fraction
  • newly diagnosed
  • gene expression
  • prognostic factors
  • copy number
  • single molecule
  • drug induced