Incidentally identified genetic variants in arrhythmogenic right ventricular cardiomyopathy-associated genes among children undergoing exome sequencing reflect healthy population variation.

Andrew T HeadrickJill A RosenfeldYaping YangHari TunuguntlaHugh D AllenDaniel J PennyJeffrey J KimAndrew P Landstrom

Published in: Molecular genetics & genomic medicine (2019)

Incidentally identified variants are common among pediatric WES testing with gene frequencies similar to "background" variants. Incidentally identified variants are unlikely to be pathologic.

Keyphrases

copy number
genome wide
dna methylation
heart failure
young adults
neoadjuvant chemotherapy
single cell
gene expression
atrial fibrillation