CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT.
Zeina R Al SayedCéline PereiraRémi Le BorgneChristine Viaris de LesegnoCharlène JouveEsthel PénardAdeline MalletNihar MasurkarGildas LoussouarnJean-Marc VerbavatzChristophe LamazeDavid Alexandre TrégouëtJean-Sébastien HulotPublished in: Circulation (2024)
Our study identifies unbridled turnover of the potassium channel hERG as a mechanism supporting the interindividual susceptibility underlying diLQT development and demonstrates how this phenomenon is finely tuned by CAVIN1.