Type 17 immunity promotes the exhaustion of CD8+ T cells in cancer.
Byung-Seok KimDa-Sol KuenChoong-Hyun KohHyung-Don KimSeon Hee ChangSehui KimYoon Kyung JeonYoung-Jun ParkGaram ChoiJiyeon KimKeon Wook KangHye Young KimSuk-Jo KangShin HwangEui-Cheol ShinChang-Yuil KangChen DongYeonseok ChungPublished in: Journal for immunotherapy of cancer (2021)
IL-17-producing cells promote terminal exhaustion of CD8+ T cells and tumor progression in vivo, which can be reversed by blockade of IL-17 or RORγt pathway. These findings unveil a novel role for IL-17-producing cells as tumor-promoting cells facilitating CD8+ T cell exhaustion, and propose type 17 immunity as a promising target for cancer immunotherapy.