Two-Dimensional Liquid Chromatography Purified GC/C/IRMS Doping Control Method: Analysis of Endogenous and Exogenous Sources in Urine Samples from Asian Subjects Administered a Low Dose of AICAR.
Yirang WangJingyi FanXian FangYue ZhuoSiyan XuLei LiaoXiaojun DengBing LiuPublished in: Journal of chromatography. A (2024)
This study successfully established a 2D-HPLC-GC/IRMS method that integrates CIR as the most stable indicator for distinguishing the internal and external sources of AICAR. After administering a low dose of AICAR to the Asian population, exogenous drug characteristics were manifested within 16 hours. This observation, when compared to the 40-hour detection window cited in the literature, suggests that the length of the detection window is positively correlated with the dosage of the test drug.
Keyphrases
- low dose
- liquid chromatography
- mass spectrometry
- high dose
- drinking water
- loop mediated isothermal amplification
- simultaneous determination
- tandem mass spectrometry
- systematic review
- ms ms
- real time pcr
- label free
- blood pressure
- high performance liquid chromatography
- high resolution mass spectrometry
- solid phase extraction
- adverse drug
- high resolution