Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer.
Nathan D PennockHolly A MartinsonQiuchen GuoCourtney B BettsSonali JindalTakahiro TsujikawaLisa M CoussensVirginia F BorgesPepper J SchedinPublished in: Journal for immunotherapy of cancer (2018)
Ibuprofen administration during the tumor promotional microenvironment of the involuting mammary gland reduces overall tumor growth and enhances anti-tumor immune characteristics while avoiding adverse autoimmune reactions. In sum, these studies implicate beneficial prophylactic use of ibuprofen during the pro-tumorigenic window of mammary gland involution.