Genomic profiling of NGS-based ctDNA from Chinese non-small cell lung cancer patients.

Yanfeng XiZhongyuan BaiSihang GaoJianghong GuoZhen ZhangHongling ZhangLi QuBing XuWeiwei WangGuangyu ShanWei Cui Wenqi Bai Xiaoyong Ji

Published in: Journal of cancer research and clinical oncology (2023)

The results indicate that the results of NGS-based ctDNA assay are highly consistent with ddPCR. In Chinese NSCLC patients, TP53 mutation was more frequently associated with male and squamous cell carcinoma. The prevalence of concomitant mutations in L858R may be different from that in 19del.

Keyphrases

squamous cell carcinoma
single cell
end stage renal disease
small cell lung cancer
newly diagnosed
ejection fraction
risk factors
gene expression
circulating tumor
cell therapy
stem cells
tyrosine kinase
rectal cancer