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Macrophage Motility in Wound Healing Is Regulated by HIF-1α via S1P Signaling.

Islamy Rahma HutamiTakashi IzawaTsendsuren Khurel-OchirTakuma SakamakiAkihiko IwasaEiji Tanaka
Published in: International journal of molecular sciences (2021)
Accumulating evidence indicates that the molecular pathways mediating wound healing induce cell migration and localization of cytokines to sites of injury. Macrophages are immune cells that sense and actively respond to disturbances in tissue homeostasis by initiating, and subsequently resolving, inflammation. Hypoxic conditions generated at a wound site also strongly recruit macrophages and affect their function. Hypoxia inducible factor (HIF)-1α is a transcription factor that contributes to both glycolysis and the induction of inflammatory genes, while also being critical for macrophage activation. For the latter, HIF-1α regulates sphingosine 1-phosphate (S1P) to affect the migration, activation, differentiation, and polarization of macrophages. Recently, S1P and HIF-1α have received much attention, and various studies have been performed to investigate their roles in initiating and resolving inflammation via macrophages. It is hypothesized that the HIF-1α/S1P/S1P receptor axis is an important determinant of macrophage function under inflammatory conditions and during disease pathogenesis. Therefore, in this review, biological regulation of monocytes/macrophages in response to circulating HIF-1α is summarized, including signaling by S1P/S1P receptors, which have essential roles in wound healing.
Keyphrases
  • wound healing
  • oxidative stress
  • endothelial cells
  • cell migration
  • transcription factor
  • adipose tissue
  • gene expression
  • escherichia coli
  • genome wide
  • pseudomonas aeruginosa
  • cystic fibrosis
  • candida albicans