Moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas (HYPORT-STS): Updated local control, late toxicities, and patient-reported outcomes.
Andrew J BishopDevarati MitraAhsan FarooqiDavid M SwansonCaroline HempelTiara WillisChris PearlnathWei-Lien WangRavin RatanNeeta SomaiahRobert S BenjaminKeila E TorresKelly K HuntChristopher P ScallyEmily Z KeungRobert L SatcherJustin E BirdPatrick P LinBryan S MoonValerae O LewisChristina Lynn RolandB Ashleigh GuadagnoloPublished in: Cancer (2024)
Long-term follow up suggests that moderately hypofractionated preoperative RT for patients with STS is safe and effective. Higher grade late toxicities affect a minority of patients. Late toxicities decrease over time, whereas functional outcomes and health-related quality of life seem to improve with more time from combined modality treatment.