Pulmonary vascular dysfunction in metabolic syndrome.
Conor WillsonMakiko WatanabeAtsumi Tsuji-HosokawaAyako MakinoPublished in: The Journal of physiology (2018)
Metabolic syndrome is a critically important precursor to the onset of many diseases, such as cardiovascular disease, and cardiovascular disease is the leading cause of death worldwide. The primary risk factors of metabolic syndrome include hyperglycaemia, abdominal obesity, dyslipidaemia, and high blood pressure. It has been well documented that metabolic syndrome alters vascular endothelial and smooth muscle cell functions in the heart, brain, kidney and peripheral vessels. However, there is less information available regarding how metabolic syndrome can affect pulmonary vascular function and ultimately increase an individual's risk of developing various pulmonary vascular diseases, such as pulmonary hypertension. Here, we review in detail how metabolic syndrome affects pulmonary vascular function.
Keyphrases
- metabolic syndrome
- pulmonary hypertension
- insulin resistance
- cardiovascular disease
- uric acid
- cardiovascular risk factors
- blood pressure
- smooth muscle
- risk factors
- pulmonary artery
- type diabetes
- pulmonary arterial hypertension
- heart failure
- stem cells
- single cell
- oxidative stress
- adipose tissue
- mesenchymal stem cells
- coronary artery disease
- multiple sclerosis
- white matter
- body mass index
- subarachnoid hemorrhage
- functional connectivity
- social media
- cerebral ischemia
- high fat diet induced