Cu(OTf) 2 /HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles.

Srinivasarao YaragorlaTabassum KhanSayonika Chakroborty

Published in: Organic & biomolecular chemistry (2024)

We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles using Cu(OTf) 2 /HFIP as the excellent promoter system. The reaction proceeds through a one-pot, domino process of spiro cyclization and 1,2-migration followed by aromatization to deliver carbazoles.

Keyphrases

electron transfer
dna methylation
aqueous solution
gene expression
transcription factor
room temperature
quantum dots
molecular dynamics
metal organic framework
molecularly imprinted
ionic liquid
life cycle
liquid chromatography
tandem mass spectrometry