Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation.
Anu Mary VargheseMausam GhoshSavita Kumari BhagatK VijayalakshmiVeeramani Preethish-KumarSeena VengalilPradeep-Chandra-Reddy ChevulaSaraswati NashiKiran PolavarapuMeenakshi SharmaRupinder Singh DhaliwalMariamma PhilipAtchayaram NaliniPhalguni Anand AlladiTalakad N SathyaprabhaTrichur R RajuPublished in: Journal of neuroinflammation (2020)
CHIT-1, an early diagnostic biomarker of sporadic ALS, activates glia priming them to attain a toxic phenotype resulting in neuroinflammation leading to motor neuronal death.