Reduced chromatin acetylation of malignant salivary gland tumors correlates with enhanced proliferation.

Vivian Petersen WagnerManoela Domingues MartinsDouglas Magno GuimaraesArtur Cunha VasconcelosLuise MeurerPablo Agustin VargasFelipe Paiva FonsecaCristiane Helena SquarizeRogerio de Moraes Castilho

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2017)

This study provides the first insight regarding histone modifications in SGTs. Our results suggest that epigenetic mechanism, particularly hypoacetylation of histone H3 (lys9), might play a role in the behavior of salivary gland tumors. Also, our findings suggest that interfering with the acetylation pattern of tumor histones represents a potential novel therapeutic strategy for the treatment of SGTs.

Keyphrases

dna methylation
gene expression
dna damage
genome wide
signaling pathway
histone deacetylase
transcription factor
human health