Empagliflozin Enhances Autophagy, Mitochondrial Biogenesis, and Antioxidant Defense and Ameliorates Renal Ischemia/Reperfusion in Nondiabetic Rats.

Moein AlaMohammad Reza Fallahpour KhoshdelAhmad Reza Dehpour

Published in: Oxidative medicine and cellular longevity (2022)

Empagliflozin improved renal I/R injury in nondiabetic rats in this study by promoting autophagy and mitochondrial biogenesis and attenuation of oxidative stress, inflammation, and apoptosis.

Keyphrases

oxidative stress
diabetic rats
dna damage
ischemia reperfusion injury
induced apoptosis
endoplasmic reticulum stress
cell death
mouse model
anti inflammatory