MTOR suppresses autophagy-mediated production of IL25 in allergic airway inflammation.
Wen LiYinfang WuYun ZhaoZhou-Yang LiHaixia ChenLingling DongHuiwen LiuMin ZhangYanping WuJiesen ZhouJuan XiongYue HuWen HuaBin ZhangMinzhi QiuQing-Ling ZhangChunhua WeiMingchun WenJing HanXiaobo ZhouWeiliang QiuFugui YanHuaqiong HuangSongmin YingAugustine M K ChoiHuahao ShenZhihua ChenPublished in: Thorax (2020)
Collectively, these results demonstrate that allergen-initiated inflammation suppresses MTOR and induces autophagy in airway epithelial cells, which results in the production of certain proallergic cytokines such as IL25, further promoting the type 2 response and eventually perpetuating airway inflammation in asthma.