Proton pump inhibitors and myocardial infarction: an application of active comparators in a self-controlled case series.
Celine S L ChuiKa Shing CheungJeremy Philip BrownIan J DouglasIan C K WongEsther W ChanAngel Y S WongPublished in: International journal of epidemiology (2022)
We observed no difference in risk of MI associated with PPIs compared with baseline using H2RA as the active comparator. The elevated risk of MI associated with PPIs is likely due to protopathic bias. More studies are required to explore the feasibility of using active comparators in SCCS to address protopathic bias in addition to confounding.