Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of the fibrilar and non-fibrilar structures.
Jessica PingelMikkel Schou NielsenTorsten LauridsenKristian RixMartin BechTine AlkjaerIda Torp AndersenJens Bo NielsenR FeidenhanslPublished in: Scientific reports (2017)
The present study reveals that high dose intramuscular BoNT/A injections cause microstructural damage of the muscle tissue, which contributes to impaired gait.