Maternal Immune Activation Induces Cortical Catecholaminergic Hypofunction and Cognitive Impairments in Offspring.

Blanca Perez-PalomarAmaia M ErdozainInes Erkizia-SantamaríaJorge E OrtegaJ Javier Meana

Published in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2023)

MIA induces in offspring a presynaptic catecholaminergic hypofunction in PFC with cognitive impairment. This poly(I:C)-based model reproduces catecholamine phenotypes reported in schizophrenia and represents an opportunity for the study of cognitive impairment associated to this disorder.

Keyphrases

cognitive impairment
high fat diet
bipolar disorder
type diabetes
pregnancy outcomes
gestational age