Untargeted metabolomics using UHPLC-Q-Orbitrap HRMS for identifying cytotoxic compounds on MCF-7 breast cancer cells from Annona muricata Linn leaf extracts as potential anticancer agents.
Dewi Anggraini SeptaningsihIrma Herawati SupartoSuminar Setiati AchmadiRudi HeryantoMohamad RafiPublished in: Phytochemical analysis : PCA (2024)
Untargeted metabolomics and in silico modeling identified cytotoxic compounds on MCF-7 cells and binding affinity to 3ERT in A. muricata leaf extracts. The findings need to be further verified to prove the screening results.
Keyphrases
- mass spectrometry
- high resolution mass spectrometry
- liquid chromatography
- breast cancer cells
- ultra high performance liquid chromatography
- gas chromatography
- capillary electrophoresis
- induced apoptosis
- tandem mass spectrometry
- simultaneous determination
- cell cycle arrest
- high resolution
- ms ms
- solid phase extraction
- endoplasmic reticulum stress
- human health
- oxidative stress
- cell death
- risk assessment
- gas chromatography mass spectrometry
- climate change
- binding protein
- dna binding
- cell proliferation
- transcription factor
- young adults