Association between body mass index, dosing strategy, and efficacy of immune checkpoint inhibitors.

Murtaza AhmedMitchell S von ItzsteinThomas SheffieldShaheen KhanFarjana FattahJason Y ParkVinita PopatJessica M SaltarskiYvonne Gloria-McCutchenDavid HsiehchenJared OstmeyerSaad A KhanNazima SultanaYang XieQuan-Zhen LiEdward K WakelandDavid E Gerber

Published in: Journal for immunotherapy of cancer (2022)

The clinical benefit of ICI in high-BMI populations appears limited to individuals receiving weight-based ICI dosing. Further research into optimal ICI dosing strategies may be warranted.

Keyphrases

body mass index
weight gain
physical activity
weight loss
genetic diversity
body weight