Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts.
Matthew W RosenbaumMartin JonesJonathan C DudleyLong P LeA John IafrateMartha B PitmanPublished in: Cancer cytopathology (2016)
The detection of KRAS/GNAS variants improves the identification of mucinous neoplasms. Variants in TP53, SMAD4, CDKN2A, and NOTCH1 support the diagnosis of a high-risk cyst requiring surgery or additional sampling. Although molecular analysis is not a replacement for cytopathology, it does provide valuable information for accurate preoperative diagnosis, helping to classify mucinous neoplasms and high-risk cysts that require surgical resection. Cancer Cytopathol 2017;125:41-47. © 2016 American Cancer Society.
Keyphrases
- papillary thyroid
- copy number
- squamous cell
- low grade
- patients undergoing
- minimally invasive
- cell proliferation
- epithelial mesenchymal transition
- healthcare
- high resolution
- mass spectrometry
- childhood cancer
- coronary artery disease
- high grade
- acute coronary syndrome
- loop mediated isothermal amplification
- percutaneous coronary intervention
- circulating tumor