Large-Scale Whole-Genome Analysis of HTLV-1-Associated Myelopathy Identified Hereditary Spastic Paraplegias.
Naoki TakaoNaoko YagishitaNatsumi ArayaSatoko ArataniJunji YamauchiKatsunori TakahashiYasuo KunitomoTomoo SatoMasahiro NakamoriYosuke KawaiYosuke OmaeKatsushi TokunagaFumihiko MatsudaSatomi MitsuhashiYoshihisa YamanoPublished in: Neurology. Genetics (2024)
Genetic analysis is useful for the differentiation of hereditary spastic paraplegia patients from HTLV-1-associated myelopathy patients, especially for the patients with low levels of CSF inflammatory markers. Here we report the presence of hereditary spinal cord diseases in patients diagnosed with HTLV-1-associated myelopathy and provides evidence that genetic analysis would be helpful in the diagnostic workflow.