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Faecal Microbiota Transplantation, Paving the Way to Treat Non-Alcoholic Fatty Liver Disease.

María Del BarrioLucía LavínÁlvaro Santos-LasoMaria Teresa Arias-LosteAitor OdriozolaJuan Carlos Rodriguez-DuqueCoral RivasPaula IruzubietaJavier Crespo
Published in: International journal of molecular sciences (2023)
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent cause of chronic liver disease (CLD). Currently, the only therapeutic recommendation available is a lifestyle change. However, adherence to this approach is often difficult to guarantee. Alteration of the microbiota and an increase in intestinal permeability seem to be key in the development and progression of NAFLD. Therefore, the manipulation of microbiota seems to provide a promising therapeutic strategy. One way to do so is through faecal microbiota transplantation (FMT). Here, we summarize the key aspects of FMT, detail its current indications and highlight the most recent advances in NAFLD.
Keyphrases
  • cardiovascular disease
  • endothelial cells
  • physical activity
  • metabolic syndrome
  • type diabetes
  • cell therapy
  • liver fibrosis
  • stem cells
  • weight loss
  • skeletal muscle
  • glycemic control