Genotype-phenotype relationship and risk stratification in loss-of-function SCN5A mutation carriers.
Tomas RobynsDieter NuyensBert VandenberkCuno KuiperiAnniek CorveleynJeroen BreckpotChristophe GarwegJoris EctorRik WillemsPublished in: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2018)
LP were more frequently observed in SCN5A mutation carriers, while fQRS was not. In SCN5A mutation carriers, the annual incidence rate of SCD was non-negligible, even in the absence of a spontaneous or induced type 1 ECG. Therefore, proper follow-up of SCN5A mutation carriers without Brugada syndrome phenotype is warranted.