ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network.
Michelle B AtallahVarun TandonKamir J HiamHunter BoyceMichelle HoriWaleed AtallahMatthew H SpitzerEdgar EnglemanParag MallickPublished in: BMC bioinformatics (2020)
While the fields of proteomics and genomics have long benefited from network analysis tools, no such tool yet exists for immunology. ImmunoGlobe provides a ground truth immune interaction network upon which such tools can be built. These tools will allow us to predict the outcome of complex immune interactions, providing mechanistic insight that allows us to precisely modulate immune responses in health and disease.