Genetic variations of antioxidant genes and their association with male infertility in Vietnamese men.
Huy Anh BachPhuong Nhung VuThi Huyen Thuong MaHai Ha NguyenPhan Tran DucDuc Bui MinhVan Hai NongNguyen Dang TonPublished in: Journal of clinical laboratory analysis (2023)
We identified SOD1:7958GA genotype and NOS3:-786CT genotype in the infertility group were significantly higher than in the control with OR = 2.191 (95% CI: 1.226-3.915, p = 0.004) and OR = 3.135 (95% CI: 1.591-6.180, p < 0.001), respectively. We also detected that the frequency of the SOD2:c.47TC genotype was significantly higher in the male infertility group than in fertile men (OR = 1.941, 95% CI: 1.063-3.595, p = 0.029). Gene-gene interactions between the SNPs of SOD1, SOD2, and CAT might increase the risk of male infertility patients. In particular, patients carrying the SOD1:GA+AA, SOD2:TC+CC, and CAT:CT/TT genotype pattern have an increased risk of male infertility (OR = 7.614, p = 0.007). To our knowledge, this is the first study to evaluate the association between the SOD1:7958G>A polymorphism and male infertility. Further studies with larger sample sizes and more genes are needed to better assess the association between variants of antioxidant genes and male infertility.
Keyphrases
- genome wide
- amyotrophic lateral sclerosis
- end stage renal disease
- polycystic ovary syndrome
- copy number
- newly diagnosed
- genome wide identification
- chronic kidney disease
- ejection fraction
- computed tomography
- oxidative stress
- prognostic factors
- healthcare
- gene expression
- type diabetes
- patient reported outcomes
- anti inflammatory
- positron emission tomography
- magnetic resonance
- transcription factor